Anti-Mouse Ly-6A/E (Sca-1) PE-Cy5.5 (See Replacement Format PerCP-Cy5.5 45-5981)

Also known as: Sca1, Ly6AE, Ly6A, Ly6E

Clone: D7

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Discontinued. See Replacement Format PerCP-Cy5.5 45-5981

SKU# 35-5981

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Description

Description: The D7 monoclonal antibody reacts with mouse Sca-1, an 18 kDa member of the Ly-6 family of GPI-linked surface proteins. D7 reacts with both Ly-6E.1 and Ly-6A.2 molecules expressed by mouse hematopoietic stem cells, myeloid population and peripheral T and B cells. Non-activated splenocytes from Ly-6.2 strains including C57BL, SJL, 129, AKR, and others demonstrate higher frequency of D7-positive cells compared to the Ly-6.1 strains such as BALB/c, C3H, NZB and others. Sca-1 is expressed at high levels upon activation regardless of the Ly-6 haplotype. The Ly-6 family is involved in regulation and function of T cell activation. Sca-1 is a major phenotypic marker for mouse hematopoietic progenitor/stem cell subset.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Emit	690 nm
Excite	488 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
25-5981	Anti-Mouse Ly-6A/E (Sca-1) PE-Cy7	488 nm	760 nm	FC	RUO
16-5981	Anti-Mouse Ly-6A/E (Sca-1) Functional Grade Purified			FC, FA	RUO
93-5981	Anti-Mouse Ly-6A/E (Sca-1) eFluor® 605NC	350 - 590 nm	605 nm	FC	RUO
15-5981	Anti-Mouse Ly-6A/E (Sca-1) PE-Cy5	488 nm	670 nm	FC	RUO
11-5981	Anti-Mouse Ly-6A/E (Sca-1) FITC	488 nm	518 nm	FC	RUO
17-5981	Anti-Mouse Ly-6A/E (Sca-1) APC	633 nm	660 nm	FC	RUO
14-5981	Anti-Mouse Ly-6A/E (Sca-1) Purified			FC, IP, WB	RUO
45-5981	Anti-Mouse Ly-6A/E (Sca-1) PerCP-Cy5.5 (PE-Cy5.5 replacement)	488 nm	690 nm	FC	RUO
12-5981	Anti-Mouse Ly-6A/E (Sca-1) PE	488 nm	575 nm	FC	RUO
56-5981	Anti-Mouse Ly-6A/E (Sca-1) Alexa Fluor® 700	633 nm	723 nm	FC	RUO
13-5981	Anti-Mouse Ly-6A/E (Sca-1) Biotin			FC	RUO

References

References:
Ortega, G., P. E. Korty, et al. (1986). "Role of Ly-6 in lymphocyte activation. I. Characterization of a monoclonal antibody to a nonpolymorphic Ly-6 specificity." J Immunol 137(10): 3240-6.
Malek, T. R., G. Ortega, et al. (1986). "Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies." J Exp Med 164(3): 709-22.

View More Products

Antigens	Area of Biology	Cell Type
Ly-6A/E (Sca-1)	Innate Immunity	B Cells Hematopoietic Stem Cells T Cells