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Mouse LIF Recombinant Protein Carrier-Free

Also known as: leukocyte inhibitory factor, Leukemia inhibitory factor

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 34-8521

Cat. No. Size
34-8521-82 100 ug
34-8521-85 500 ug

Data for Mouse LIF Recombinant Protein Carrier-Free.

Standard four-parameter fit to induction of mouse IL-6 in the M1 cell line by Mouse LIF Recombinant...View More

  • Data for Mouse LIF Recombinant Protein Carrier-Free.
Description

Description: Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.

Details
Reactivity Mouse
Purity > 98%, as determined by SDS-PAGE
Molecular Mass 20 kDa
Reported Applications Cytokine Bioassays
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-8521 Mouse LIF Recombinant Protein FA RUO
References

References: Mullen EM, Gu P, Cooney AJ. Nuclear receptors in regulation of mouse ES pluripotency and differentiation. PPAR Res. 2007;2007:61563

Metcalf D. The unsolved enigmas of leukemia inhibitory factor. Stem Cells. 2003;21(1):5-14

Gadient RA, Patterson PH. Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: roles in inflammation and injury. Stem Cells. 1999;17(3):127-137