Mouse IP-10 FlowCytomix Simplex

Description: This FlowCytomix Simplex Kit is designed for the measurement of Mouse IP-10 in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Mouse Basic Kit (cat. BMS8440FF), this kit can be used to detect IP-10 alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.

This kit contains bead population A3.

IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. The Interferon-gamma inducible protein -10kD (IP-10) displays pleiotropic functions including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis.

Through this inhibitory effect on neovascularization IP-10 exhibits anti-tumoral effects. It shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer?s disease.

Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.

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HayGlass,K.T.; Gangur,V.; Campbell,J.D.; Simons,F.E.. Experimental approaches to analysis of immune dysregulation in human allergic disease. Immunopharmacology 2000;48:283-290. (Link)

Strieter,R.M.; Polverini,P.J.; Arenberg,D.A.; Kunkel,S.L.. The role of CXC chemokines as regulators of angiogenesis. Shock 1995;4:155-160. (Link)

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Sebastiani,S.; Albanesi,C.; De,P.O.; Puddu,P.; Cavani,A.; Girolomoni,G.. The role of chemokines in allergic contact dermatitis. Arch.Dermatol Res 2002;293:552-559. (Link)

Huang,D.; Han,Y.; Rani,M.R.; Glabinski,A.; Trebst,C.; Sorensen,T.; Tani,M.; Wang,J.; Chien,P.; O'Bryan,S.; Bielecki,B.; Zhou,Z.L.; Majumder,S.; Ransohoff,R.M.. Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation. Immunol Rev. 2000;177:52-67. (Link)

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Huang,D.; Han,Y.; Rani,M.R.; Glabinski,A.; Trebst,C.; Sorensen,T.; Tani,M.; Wang,J.; Chien,P.; O'Bryan,S.; Bielecki,B.; Zhou,Z.L.; Majumder,S.; Ransohoff,R.M.. Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation. Immunol.Rev. 2000;177:52-67. (Link)

Gangur,V.; Birmingham,N.P.; Thanesvorakul,S.. Chemokines in health and disease. Vet.Immunol Immunopathol. 2002;86:127-136. (Link)

Kaplan,A.P.. Chemokines, chemokine receptors and allergy. Int Arch.Allergy Immunol 2001;124:423-431. (Link)

Romagnani,P.. From basic science to clinical practice: use of cytokines and chemokines as therapeutic targets in renal diseases. J Nephrol. 2005;18:229-233. (Link)

Xia,M.Q.; Hyman,B.T.. Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. J.Neurovirol. 1999;5:32-41. (Link)

Galkina,E.; Ley,K.. Leukocyte influx in atherosclerosis. Curr.Drug Targets 2007;8:1239-1248. (Link)

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Tsunoda,I.; Lane,T.E.; Blackett,J.; Fujinami,R.S.. Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult.Scler. 2004;10:26-34. (Link)

Neville,L.F.; Mathiak,G.; Bagasra,O.. The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cytokine Growth Factor Rev. 1997;8:207-219. (Link)

Zeremski,M.; Petrovic,L.M.; Talal,A.H.. The role of chemokines as inflammatory mediators in chronic hepatitis C virus infection. J Viral Hepat. 2007;14:675-687. (Link)

Sorensen,T.L.. Targeting the chemokine receptor CXCR3 and its ligand CXCL10 in the central nervous system: potential therapy for inflammatory demyelinating disease?. Curr.Neurovasc.Res 2004;1:183-190. (Link)

Sebastiani,S.; Albanesi,C.; De,P.O.; Puddu,P.; Cavani,A.; Girolomoni,G.. The role of chemokines in allergic contact dermatitis. Arch.Dermatol.Res. 2002;293:552-559. (Link)

Braunersreuther,V.; Mach,F.; Steffens,S.. The specific role of chemokines in atherosclerosis. Thromb.Haemost. 2007;97:714-721. (Link)

Rotondi,M.; Lazzeri,E.; Romagnani,P.; Serio,M.. Role for interferon-gamma inducible chemokines in endocrine autoimmunity: an expanding field. J Endocrinol Invest 2003;26:177-180. (new Enterprise.Tabs('collateral-tabs')