Mouse IL-9 Recombinant Protein

Description: Interleukin-9 (IL-9) is a 14 kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations. The receptor, which is a heterodimer of the γ chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand. Since the discovery of IL-9, numerous other functions have been observed. It induces Th17 and T_reg differentiation in CD4⁺ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells. IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells. Th9 cells, a newly discovered subset of CD4⁺ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10. These cells are derived from Th2 cells reprogrammed by the presence of TGFβ, making IL-9 the probable mechanism by which TGFβ drives Th17 and T_reg differentiation.

Mouse and human IL-9 share 69% sequence homology at the nucleotide level and 57% at the protein level. Although mouse IL-9 exhibits cross-species activity, human IL-9 is species-specific.

References: Cheng G, Arima M, Honda K, Hirata H, Eda F, Yoshida N, Fukushima F, Ishii Y, Fukuda T. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am J Respir Crit Care Med. 2002 Aug 11; 166(3): 406-16.

Elvaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, Van Snick J, Renauld JC, Kuchroo VK, Khoury SJ. IL-9 induces differentiation of Th17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci USA. 2009 Aug 4; 106(31): 12885-90.

Renauld JC, Kermouni A, Vink A, Louahed J, Van Snick J. Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis. J Leukoc Biol. 1995 Mar; 57(3): 353-60.