Description: The mouse IL-28 ELISA is an enzyme-linked immunosorbent assay for
the quantitative detection of mouse IL-28. The mouse IL-28 ELISA is
for research use only. Not for diagnostic or therapeutic
The IFN-lambda family signals through a heterodimeric receptor of which one subunit, IL-10R2, is shared with other members of the superfamily. The second subunit, IFN-lambdaR1 or IL-28Ra, is unique to the IFN-lambdas. Signaling occurs through the Jak/STAT pathway in a similar manner to signaling by the type I IFNs (IFN-a/ß) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral, antitumor, and antiproliferative effects, making the IFN-lambdas potential alternatives to IFN-a for anticancer and antiviral therapies. Unlike the type I IFNs, which are able to stimulate most cells, response to IFN-lambda stimulation appears to be limited to dendritic, epithelial, and some tumor cells. Another notable difference is the ability of the IFN-lambda stimulation to drive dendritic cells towards the production of CD4+CD25+FoxP3+ regulatory T-cells, suggesting a possible immunoregulatory role.