Mouse IL-23 Platinum ELISA

Description: The mouse IL-23 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse IL-23. The mouse IL-23 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

>Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rbeta1 receptor, but not IL-12Rbeta2.
IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naive T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-gamma production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases.

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Aggarwal,S.; Ghilardi,N.; Xie,M.H.; de Sauvage,F.J.; Gurney,A.L.. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003;278:1910-1914. (Link)

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Vandenbroeck,K.; Alloza,I.; Gadina,M.; Matthys,P.. Inhibiting cytokines of the interleukin-12 family: recent advances and novel challenges. J Pharm.Pharmacol 2004;56:145-160. (Link)

Brombacher,F.; Kastelein,R.A.; Alber,G.. Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends Immunol. 2003;24:207-212. (Link)

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