Anti-Mouse IL-22 PE

Description: The 1H8PWSR monoclonal antibody reacts with mouse interleukin(IL)-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-ß, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complexon target cells to induce the expression of anti-microbial peptides ß-defensin-2 and ß-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut.

References: Ota N, Wong K, Valdez PA, Zheng Y, Crellin NK, Diehl L, Ouyang W.IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol. 2011 Aug 28 doi: 10.1038/ni.2089.(1H8PWSR, FC, PubMed)

Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Holscher C, Honig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A. Regulated Expression of Nuclear Receptor RORgammat Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORgammat(+) Innate Lymphocytes. Immunity. 2010 Nov 24;33(5):736-51. (IH8PWSR, IC flow, PubMed)

Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A.Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis. J Invest Dermatol. 2009 Mar 19.

Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, Mao H, Nuovo G, Yu J, Caligiuri MA. Stage three immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22. Blood. 2009 May;87(5):451-4.

Aujla SJ, Kolls JK. IL-22: A critical mediator in mucosal host defense. J Mol Med.2009 May;87(5):451-4.

Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T(H)17 cells. Nature. 2008 Jun 19;453(7198):1051-7.