Mouse IL-21 Recombinant Protein Carrier-Free

Also known as: Interleukin-21, IL21

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8211

Cat. No.	Size
34-8211-82	100 ug
34-8211-85	500 ug

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Description

Description: Mouse Interleukin-21 (IL-21) is a 146-amino acid protein with 57% identity to the human gene. It contains a 24-amino acid signal peptide and a 4-helix-bundle cytokine domain homologous to IL-2, IL-4 and IL-15. IL-21 stimulates B cell proliferation in an anti-CD40 dependent manner but inhibits B cell proliferation stimulated by IL-4 plus anti-IgM. IL-21 is induced by IL-6 in activated T cells, a process that is dependent on STAT3 but not on ROR-gamma. IL-21 induces Th17 differentiation and suppresses FOXP3 expression, which requires STAT3 and ROR-gamma.

Details

Reactivity	Mouse
Purity	Greater than 98% as determined by SDS-PAGE.
Molecular Mass	The protein is not methionylated at the N-terminus and has a predicted molecular mass of 14,373. The non-reduced or DTT reduced protein migrates as a 15 kDa polypeptide on SDS-PAGE.
Reported Applications	Cytokine Bioassays

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
39-8211	Mouse IL-21 Single-Use ELISA RSG Standard			ELISA	RUO
14-8211	Mouse IL-21 Recombinant Protein			ELISA, FA	RUO

References

References: Korn, T. et al. 2007. Nature. 448:484-487

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-21	Adaptive Immunity Cytokines, Chemokines, Growth Factors	B Cells T Cells Th17 Cells Tfh Cells	Recombinant Proteins Carrier Free