Mouse IL-2 Platinum ELISA

Description: The mouse IL-2 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse IL-2. The mouse IL-2 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Interleukin-2 (IL-2) plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 plays a pivotal role in for the expansion of most T-cells, natural killer cells and B-cells during certain phases of their response. Antigen-specific proliferation of helper and cytotoxic T-lymphocytes following stimulation is critically dependent on IL-2 expression, secretion, and binding to receptors in an autocrine fashion on the surface of T cells. Apart from its most important role to mediate antigen specific T lymphocyte proliferation, IL-2 modulates the expression of interferon gamma and major histocompatibility antigens, stimulates proliferation and differentiation of activated B and NK cells, augments natural killer cell activity and inhibits granulocyte-macrophage colony formation. Alterations in the ability of T cells to synthesize IL-2 have been observed in physiologic and pathologic states.

Citations: Ding,Qing; Lu,Liming; Wang,Baolong; Zhou,Yun; Jiang,Yang; Zhou,Xiaorong; Xin,Lijun; Jiao,Zhijun; Chou,Kuang Yen. B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells. The Journal of Immunology 2006;177:3606-3614. (Link)

Jazayeri,Mohammad; Soleimanjahi,Hoorieh; Fotouhi,Fatemeh; Pakravan,Nafiseh. Comparison of intramuscular and footpad subcutaneous immunization with DNA vaccine encoding HSV-gD2 in mice. Comparative Immunology, Microbiology and Infectious Diseases 2009;32:453-461. (Link)

Lei,Li; Altstaedt,Julia; der Ohe,Maren; Proft,Thomas; Gross,Ulrike; Rink,Lothar. Induction of interleukin-8 in human neutrophils after MHC class II cross-linking with superantigens. Journal of Leukocyte Biology 2001;70:80-86. (Link)

Chen,Kang; Lu,Jinhua; Wang,Lei; Gan,Yunn Hwen. Mycobacterial heat shock protein 65 enhances antigen cross-presentation in dendritic cells independent of Toll-like receptor 4 signaling. Journal of Leukocyte Biology 2003;jlb(Link)

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Cornaby,A.; Simpson,M.; Vann,Rice R.; Dempsey,R.; Madras,P.; Jenkins,R.; Monaco,A.. Interleukin 2 levels and urine cytology distinguish between cyclosporine toxicity and rejection in renal and liver allograft recipients. Transplant Proc. 1988;20:827-830. (Link)