Mouse IL-19 Recombinant Protein

Description: IL-19 is a recently-discovered member of the IL-10 superfamily of cytokines. It is expressed primarily by monocytes in response to LPS, IL-4, or GM-CSF. The IL-19 receptor complex is shared with IL-24 and IL-20 and is composed of the IL-20R1 and IL-20R2 subunits. IL-19 stimulates monocytes to produce IL-6 and TNF-α. It also triggers apoptosis and the production of reactive oxygen species. IL-19 has also been reported to upregulate Th2 cytokines in CD4+ T cells and to inhibit Th1 responses, such as IFN-γ expression. Elevated levels of IL-19 have been observed in asthmatic patients, further indicating a possible role for IL-19 in the differentiation of the Th2 lineage.

References: Commins S, Steinke JW, Borish L. The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. J Allergy Clin Immunol. 2008 May; 121(5): 1108-11.

Liao SC, Cheng YC, Wang YC, Wang CW, Yang SM, Yu CK, Shieh CC, Cheng KC, Lee MF, Chiang SR, Shieh JM, Chang MS. IL-19 induced Th2 cytokines and was up-regulate in asthma patients. J Immunol. 2004 Dec 1: 173(11): 6712-8.

Liao YC, Liang WG, Chen FW, Hsu JH, Yang JJ, Chang MS. IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha. J Immunol. 2002 Oct 15; 169(8): 4288-97.