Description: The mouse IL-17F ELISA is an enzyme-linked immunosorbent assay for
the quantitative detection of mouse IL-17F. The mouse IL-17F ELISA is
for research use only. Not for diagnostic or therapeutic
procedures.
IL-17F and 17A are closely related members of the IL-17 cytokine family, sharing about 50% amino acid identity. Expression of IL-17F and IL-17A has been detected in activated human peripheral blood lymphocytes. It has been shown that the cytokines are expressed in activated human CD4+ T cells. Expression of IL-17F and IL-17A has also been observed in tissue samples from various autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease, and asthma.
The crystal structure of IL-17F has been solved and shows that the protein forms a disulfide-linked dimeric glycoprotein. IL-17A is also a disulfide-linked homodimeric glycoprotein. The IL-17F homodimer includes a classical cysteine knot motif, which is found in the TGF-beta, bone morphogenetic protein, and nerve growth factor superfamilies. One difference in the cysteine knot motif of IL-17F compared with the other known cysteine knot protein families is that it only utilizes four cysteines instead of the classical six cysteines to form the knot. IL-17F and IL-17A have been shown to form biologically active IL-17F/IL-17A heterodimers, in addition to the IL-17F and IL-17A homodimers.
