Mouse IL-17E (IL-25) Recombinant Protein Carrier-Free

Also known as: Interleukin-25, IL25, Interleukin 17E, IL-17E

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8175

Cat. No. Size
34-8175-82 100 ug
34-8175-85 500 ug

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Data for Mouse IL-17E (IL-25) Recombinant Protein Carrier-Free.

Description

Description: IL-17E (also known as IL-25) is a member of the IL-17 family, which is comprised of six proteins (IL-17A through IL-17F). IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Mouse IL-17E shares 24% to 32% sequence identity with the other mouse IL-17 family members. Mouse IL-17E cDNA encodes a 169 amino acid precursor protein with a putative 16 amino acid signal peptide. Mature mouse IL-17E shares 76% amino acid sequence identity with mature human IL-17E. The recombinant mouse IL-17E is a disulfide-linked homodimer composed of a 17.6 kDa monomeric subunit.

Details
Reactivity Mouse
Purity Greater than 96% as determined by SDS-PAGE
Molecular Mass This protein is methionylated at the N-terminus and has a predicted molecular mass of 34,950 daltons. The DTT reduced protein migrates as a 17 kDa polypeptide. The non-reduced cysteine- linked protein migrates at 34 kDa protein on non-reducing SDS-PAGE.
Endotoxin Level Less than 0.01 ng/ug cytokine as determined by the LAL assay.
Reported Applications Functional Assays
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-8175 Mouse IL-17E (IL-25) Recombinant Protein FA RUO
References

References: Kleinschek, M. A. Owyang, A. M. Joyce-Shaikh, B. Langrish, C. L. Chen, Y. Gorman, D. M. Blumenschein, W. M. McClanahan, T. Brombacher, F. Hurst, S. D. Kastelein, R. A. Cua, D. J. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 2007 Jan 22;204(1):161-70.

Hurst, S. D. Muchamuel, T. Gorman, D. M. Gilbert, J. M. Clifford, T. Kwan, S. Menon, S. Seymour, B. Jackson, C. Kung, T. T. Brieland, J. K. Zurawski, S. M. Chapman, R. W. Zurawski, G. Coffman, R. L. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002 Jul 1;169(1):443-53.

Fort, M. M. Cheung, J. Yen, D. Li, J. Zurawski, S. M. Lo, S. Menon, S. Clifford, T. Hunte, B. Lesley, R. Muchamuel, T. Hurst, S. D. Zurawski, G. Leach, M. W. Gorman, D. M. Rennick, D. M. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity. 2001 Dec;15(6):985-95.

Lee, J. Ho, W.-H. Maruoka, M. Corpuz, R. T. Baldwin, D. T. Foster, J. S. Goddard, A. D. Yansura, D. G. Vandlen, R. L. Wood, W. L. Gurney, A. L. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J Biol Chem. 2001 Jan 12;276(2):1660-4.