Mouse IL-17C Recombinant Protein

Description: IL-17C is a member of the IL-17 family, which is comprised of six proteins (IL-17A through IL-17F). IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. IL-17C has been reported to stimulate the release of TNF-α and IL-1β from the monocytic cell line THP-1. IL-17C shares 15% to 30% amino acid sequence identity with the other IL-17 family members. Mouse and human IL-17C share 83% amino acid sequence identity. Mouse IL-17C cDNA encodes a 194 amino acid protein with a putative 14 amino acid signal peptide. The recombinant mouse IL-17C is a disulfide-linked homodimer composed of a 20.2 kDa monomeric subunit.

References: Yamaguchi, Y. Fujio, K. Shoda, H. Okamoto, A. Tsuno, N. H. Takahashi, K. Yamamoto, K. IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. J Immunol. 2007 Nov 15;179(10):7128-36.

Hurst, S. D. Muchamuel, T. Gorman, D. M. Gilbert, J. M. Clifford, T. Kwan, S. Menon, S. Seymour, B. Jackson, C. Kung, T. T. Brieland, J. K. Zurawski, S. M. Chapman, R. W. Zurawski, G. Coffman, R. L. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol. 2002 Jul 1;169(1):443-53.

Li, H. Chen, J. Huang, A. Stinson, J. Heldens, S. Foster, J. Dowd, P. Gurney, A. L. Wood, W. I. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):773-8.