Mouse IL-17A Platinum ELISA

Description: The mouse IL-17 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse IL-17. The mouse IL-17 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Mouse IL-17 mRNA is specifically expressed by activated alpha beta TCR + CD2-CD8-T-cells, a small subset with a potentially important role in immune regulation. IL-17 induces the secretion of IL-6, IL-8, PGE2, MCP-1 and G-CSF by adherent cells like fibroblasts, keratinocytes, epithelial and endothelial cells. IL-17 is also able to induce ICAM-1 surface expression of T-cells. IL-17 has been shown to support the growth of hemopoietic progenitors, it has stimulatory effects on granulopoiesis in mice.

IL-17 may affect osteoclastic resorption and thereby mediate bone destruction accompanying some inflammatory diseases. Astrocytes produce NO when stimulated by IL-17, which suggests a possible role for IL-17 in the inflammatory diseases of the CNS. Forced expression of murine IL-17 induces immune responses and multiorgan inflammation.
Interleukin-17 is involved in the regulation of hematopoiesis and its effects are dependent on the physiological/pathological status of the organism. IL-17 expression in airways is upregulated upon allergen exposure like in allergic asthma. Its crucial role in T-cell activation suggests that IL-17 is involved in the development of autoimmune arthritis.

Citations: Chan,James; Ban,Ee Jun; Chun,Keng Hao; Wang,Shunhe; Backstrom,B.Thomas; Bernard,Claude C.A.; Toh,Ban Hock; Alderuccio,Frank. Transplantation of Bone Marrow Transduced to Express Self-Antigen Establishes Deletional Tolerance and Permanently Remits Autoimmune Disease. The Journal of Immunology 2008;181:7571-7580. (Link)

References: Schwarzenberger,P.; La,Russa,V; Miller,A.; Ye,P.; Huang,W.; Zieske,A.; Nelson,S.; Bagby,G.J.; Stoltz,D.; Mynatt,R.L.; Spriggs,M.; Kolls,J.K.. IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J.Immunol. 1998;161:6383-6389. (Link)

Miyamoto,M.; Prause,O.; Sjostrand,M.; Laan,M.; Lotvall,J.; Linden,A.. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J.Immunol. 2003;170:4665-4672. (Link)

Pan,G.; French,D.; Mao,W.; Maruoka,M.; Risser,P.; Lee,J.; Foster,J.; Aggarwal,S.; Nicholes,K.; Guillet,S.; Schow,P.; Gurney,A.L.. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. J.Immunol. 2001;167:6559-6567. (Link)

Van bezooijen,R.L.; Farih-Sips,H.C.; Papapoulos,S.E.; Lowik,C.W.. Interleukin-17: A new bone acting cytokine in vitro. J.Bone Miner.Res. 1999;14:1513-1521. (Link)

Jovcic,G.; Bugarski,D.; Petakov,M.; Stankovic,J.; Stojanovic,N.; Milenkovic,P.. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. Growth Factors 2001;19:61-71. (Link)

Kennedy,J.; Rossi,D.L.; Zurawski,S.M.; Vega,F.,Jr.; Kastelein,R.A.; Wagner,J.L.; Hannum,C.H.; Zlotnik,A.. Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells 65. J.Interferon Cytokine Res. 1996;16:611-617. (Link)

Nakae,S.; Komiyama,Y.; Nambu,A.; Sudo,K.; Iwase,M.; Homma,I.; Sekikawa,K.; Asano,M.; Iwakura,Y.. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002;17:375-387. (Link)

Nakae,S.; Saijo,S.; Horai,R.; Sudo,K.; Mori,S.; Iwakura,Y.. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc.Natl.Acad.Sci.U.S.A 2003;100:5986-5990. (Link)

Lubberts,E.; van den,Bersselaar L.; Oppers-Walgreen,B.; Schwarzenberger,P.; Coenen-de Roo,C.J.; Kolls,J.K.; Joosten,L.A.; van den Berg,W.B.. IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J.Immunol. 2003;170:2655-2662. (Link)

Fossiez,F.; Banchereau,J.; Murray,R.; Van,Kooten C.; Garrone,P.; Lebecque,S.. Interleukin-17. Int.Rev.Immunol. 1998;16:541-551. (Link)

Tartour,E.; Fossiez,F.; Joyeux,I.; Galinha,A.; Gey,A.; Claret,E.; Sastre-Garau,X.; Couturier,J.; Mosseri,V.; Vives,V.; Banchereau,J.; Fridman,W.H.; Wijdenes,J.; Lebecque,S.; Sautes-Fridman,C.. Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. 1999;59:3698-3704. (Link)

Trajkovic,V.; Stosic-Grujicic,S.; Samardzic,T.; Markovic,M.; Miljkovic,D.; Ramic,Z.; Mostarica,Stojkovic M.. Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. J.Neuroimmunol. 2001;119:183-191. (Link)

Numasaki,M.; Fukushi,J.; Ono,M.; Narula,S.K.; Zavodny,P.J.; Kudo,T.; Robbins,P.D.; Tahara,H.; Lotze,M.T.. Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003;101:2620-2627. (Link)

Hellings,P.W.; Kasran,A.; Liu,Z.; Vandekerckhove,P.; Wuyts,A.; Overbergh,L.; Mathieu,C.; Ceuppens,J.L.. Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am.J.Respir.Cell Mol.Biol. 2003;28:42-50. (Link)