Mouse IL-15 Recombinant Protein

Description: Mouse IL-15 is a 14-15 kDa factor, previously known as IL-T. IL-15 is produced by a variety of cells and has a role in the T cell-mediated immune response and the central nervous system. IL-15 binds to the β and γ subunits of the IL-2 receptor also known as CD25. IL-15 is a specific maturation factor for NK cells and mimics the BM microenvironment for NK cell development in vitro. It is reported that IL-15 delivers an anti-apoptotic and survival signal for NK, T, and B cells.

References: Gill, N. and Ashkar, A. Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against Herpes Simplex Virus 2. J Virol. 2009 Jan; 83(2) 918-926

Liew, F. and McInnes, I. Role of interleukin-15 and interleukin-18 in the inflammatory response. Ann Rheum Dis. 2002; 61(2) 100-102

Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha-chain of the IL-2 receptor. Embo J. 1995 Aug; 14(15) 3654-3663