Anti-Mouse IL-13 Alexa Fluor® 488

Also known as: Interleukin-13, IL13

Clone: eBio13A

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-7133

Cat. No.	Size
53-7133-80	25 ug
53-7133-82	100 ug
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Intracellular staining of Th2-polarized and restimulated CD4+ splenocytes with Anti-Mouse CD4...View More

Description

Description: The eBio13A antibody reacts with mouse IL-13. IL-13 is a cytokine produced mainly by Th2 cells, but also by antigen-primed CD8 T cells. IL-13 has a strong involvement in allergic inflammation and parasitic clearing and in cancer models has been shown to have either inhibitory or stimulatory activity depending on the tumor. In humans, IL-13 is found to play a role in isotype switching in B cells. IL-13 is implicating in down modulating macrophage activity, through the reduction of pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, IL-12)

Details

Host	Rat
Isotype	IgG1, kappa
Reactivity	Mouse
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
46-7133	Anti-Mouse IL-13 PerCP-eFluor® 710	488 nm	710 nm	FC	RUO
12-7133	Anti-Mouse IL-13 PE	488 - 561 nm		FC	RUO
50-7133	Anti-Mouse IL-13 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 - 647 nm	668 nm	FC	RUO
14-7133	Anti-Mouse IL-13 Purified			ELISA	RUO
48-7133	Anti-Mouse IL-13 eFluor® 450	405 nm		FC	RUO
16-7133	Anti-Mouse IL-13 Functional Grade Purified			ELISA	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
00-4975	Cell Stimulation Cocktail (plus protein transport inhibitors) (500X)			FC, FA	GPR
46-0042	Anti-Mouse CD4 PerCP-eFluor® 710	488 nm	710 nm	FC	RUO
53-4301	Rat IgG1 K Isotype Control Alexa Fluor® 488	488 nm	519 nm	FC, ICC, IHC	RUO
88-8824	Intracellular Fixation & Permeabilization Buffer Set			FC	GPR

References

References: Halim TY, Krauss RH, Sun AC, Takei F. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity. 2012 Mar 23;36(3):451-63. (eBio13A, FC, PubMed)

Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park JW, Miyahara S, Balhorn A, Dakhama A, Gelfand EW. Contribution of antigen-primed CD8+T cells to the develompent of airwary hyperresponsiveness and inflammation is associated with IL-13. J Immunol. 2004 Feb 15;172(4):2549-58.

Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18;282(5397):2261-3.

Doherty TM, Kastelein R, Menon S, Andrade S, Coffman RL. Modulation of murine macrophage function by IL-13. J Immunol. 1993 Dec 15;151(12):7151-60.

McKenzie AN, Li X, Largaespada DA, Sato A, Kaneda A, Zurawski SM, Doyle EL, Milatovich A, Francke U, Copeland NG, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol. 1993 Jun 15;150(12):5436-44.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-13	Adaptive Immunity Cytokines, Chemokines, Growth Factors	T Cells Th2 Cells	Alexa Fluor 488