Anti-Mouse IL-12/IL-23 p40 PerCP-Cyanine5.5

Also known as: Interleukin-12, IL12 / Interleukin-23, IL23 p40

Clone: C17.8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 45-7123

Cat. No.	Size
45-7123-80	25 ug
45-7123-82	100 ug
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Intracellular staining of thioglycolate-induced peritoneal exudate cells stimulated overnight with...View More

Description

Description: The C17.8 antibody reacts with the p40 subunit of IL-12 and IL-23. The C17.8 antibody has been found to neutralize IL-12 and IL-23 bioactivity. For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Conjugate	PerCP-Cyanine5.5
Laser	Blue Laser
Excite	488 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 2. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
13-7123	Anti-Mouse IL-12/IL-23 p40 Biotin			ELISA	RUO
48-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 450	405 nm		FC	RUO
50-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 nm	668 nm	FC	RUO
12-7123	Anti-Mouse IL-12/IL-23 p40 PE	488 - 561 nm		FC	RUO
16-7123	Anti-Mouse IL-12/IL-23 p40 Functional Grade Purified			FC, FA, IP, WB	RUO
53-7123	Anti-Mouse IL-12/IL-23 p40 Alexa Fluor® 488	488 nm	519 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
45-4321	Rat IgG2a K Isotype Control PerCP-Cyanine5.5	488 nm		FC	RUO
88-8823	Intracellular Fixation & Permeabilization Buffer (plus Brefeldin A) (previously named IC Fixation & Permeabilization Buffer)			FC	GPR

References

References: Cho D, Lee WJ, Halloran PJ, Trinchieri G, Kim YB. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996 Aug 25;172(1):29-34.

Aragane Y, Riemann H, Bhardwaj RS, Schwarz A, Sawada Y, Yamada H, Luger TA, Kubin M, Trinchieri G, Schwarz T. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994 Dec 15;153(12):5366-72.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-12/IL-23	Cytokines, Chemokines, Growth Factors Innate Immunity	Dendritic Cells Th1 Cells	PerCP-Cyanine5.5