Anti-Mouse IL-12/IL-23 p40 Functional Grade Purified

Also known as: Interleukin-12, IL12 / Interleukin-23, IL23 p40

Clone: C17.8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 16-7123

Cat. No.	Size
16-7123-85	500 ug
16-7123-81	50 ug
Please inquire about custom configurations or bulk packaging.

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Description

Description: The C17.8 antibody reacts with the p40 subunit of IL-12 and IL-23. The C17.8 antibody has been found to neutralize IL-12 and IL-23 bioactivity. For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Conjugate	Functional Grade Purified (low endotoxin, azide-free)
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis, Cytokine Neutralization, Immunoprecipitation, Western Blotting

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
45-7123	Anti-Mouse IL-12/IL-23 p40 PerCP-Cyanine5.5	488 nm		FC	RUO
13-7123	Anti-Mouse IL-12/IL-23 p40 Biotin			ELISA	RUO
48-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 450	405 nm		FC	RUO
53-7123	Anti-Mouse IL-12/IL-23 p40 Alexa Fluor® 488	488 nm	519 nm	FC	RUO
12-7123	Anti-Mouse IL-12/IL-23 p40 PE	488 - 561 nm		FC	RUO
50-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 nm	668 nm	FC	RUO

Related Products

Cat. No.	Name	Application	Reg.
14-7122	Anti-Mouse IL-12 p35 Purified	ELISA, FA	RUO
14-8231	Mouse IL-23 Recombinant Protein	ELISA, FA	RUO
16-4321	Rat IgG2a K Isotype Control Functional Grade Purified	FC	RUO

References

References: Cho D, Lee WJ, Halloran PJ, Trinchieri G, Kim YB. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996 Aug 25;172(1):29-34.

Aragane Y, Riemann H, Bhardwaj RS, Schwarz A, Sawada Y, Yamada H, Luger TA, Kubin M, Trinchieri G, Schwarz T. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994 Dec 15;153(12):5366-72.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-12/IL-23	Cytokines, Chemokines, Growth Factors Innate Immunity	Dendritic Cells Th1 Cells	Functional Grade Purified