Anti-Mouse IL-12/IL-23 p40 eFluor® 450

Also known as: Interleukin-12, IL12 / Interleukin-23, IL23 p40

Clone: C17.8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 48-7123

Cat. No.	Size
48-7123-80	25 ug
48-7123-82	100 ug
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Mouse thioglycolate-elicited peritoneal exudate cells were stimulated overnight with LPS and IFN...View More

Description

Description: The C17.8 antibody reacts with the p40 subunit of IL-12 and IL-23. The C17.8 antibody has been found to neutralize IL-12 and IL-23 bioactivity. For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Conjugate	eFluor 450
Laser	Violet Laser
Excite	405 nm
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
45-7123	Anti-Mouse IL-12/IL-23 p40 PerCP-Cyanine5.5	488 nm		FC	RUO
16-7123	Anti-Mouse IL-12/IL-23 p40 Functional Grade Purified			FC, FA, IP, WB	RUO
50-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 nm	668 nm	FC	RUO
13-7123	Anti-Mouse IL-12/IL-23 p40 Biotin			ELISA	RUO
53-7123	Anti-Mouse IL-12/IL-23 p40 Alexa Fluor® 488	488 nm	519 nm	FC	RUO
12-7123	Anti-Mouse IL-12/IL-23 p40 PE	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Application	Reg.
00-4506	Brefeldin A Solution (1000X)		FC	GPR
14-8311	Mouse IFN gamma Recombinant Protein		FA	RUO
48-4321	Rat IgG2a K Isotype Control eFluor® 450	405 nm	FC	RUO
65-0865	Fixable Viability Dye eFluor® 780		FC	GPR
88-8823	Intracellular Fixation & Permeabilization Buffer (plus Brefeldin A) (previously named IC Fixation & Permeabilization Buffer)		FC	GPR

References

References: Cho D, Lee WJ, Halloran PJ, Trinchieri G, Kim YB. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996 Aug 25;172(1):29-34.

Aragane Y, Riemann H, Bhardwaj RS, Schwarz A, Sawada Y, Yamada H, Luger TA, Kubin M, Trinchieri G, Schwarz T. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994 Dec 15;153(12):5366-72.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-12/IL-23	Cytokines, Chemokines, Growth Factors	Dendritic Cells Th1 Cells	eFluor 450