Anti-Mouse IL-12/IL-23 p40 Alexa Fluor® 488

Also known as: Interleukin-12, IL12 / Interleukin-23, IL23 p40

Clone: C17.8

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 53-7123

Cat. No.	Size
53-7123-80	25 ug
53-7123-82	100 ug
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Mouse thioglycolate-elicited peritoneal exudate cells were stimulated overnight with LPS and IFN...View More

Description

Description: The C17.8 antibody reacts with the p40 subunit of IL-12 and IL-23. The C17.8 antibody has been found to neutralize IL-12 and IL-23 bioactivity. For specific neutralization of IL-23 only, please see clone G23-8 (anti-mouse IL-23 p19). IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and is secreted by activated monocytes, macrophages, and dendritic cells. IL-23 is a heterodimer composed of the disulfide-linked p19 protein and p40 protein, expressed by activated dendritic cells.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Mouse
Conjugate	Alexa Fluor 488
Laser	Blue Laser
Emit	519 nm
Excite	488 nm
Legal	Alexa Fluor® is a registered trademark of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Intracellular Staining Followed by Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
16-7123	Anti-Mouse IL-12/IL-23 p40 Functional Grade Purified			FC, FA, IP, WB	RUO
45-7123	Anti-Mouse IL-12/IL-23 p40 PerCP-Cyanine5.5	488 nm		FC	RUO
50-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 660 (Alexa Fluor® 647 Replacement)	633 nm	668 nm	FC	RUO
13-7123	Anti-Mouse IL-12/IL-23 p40 Biotin			ELISA	RUO
48-7123	Anti-Mouse IL-12/IL-23 p40 eFluor® 450	405 nm		FC	RUO
12-7123	Anti-Mouse IL-12/IL-23 p40 PE	488 - 561 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
14-8311	Mouse IFN gamma Recombinant Protein			FA	RUO
53-4321	Rat IgG2a K Isotype Control Alexa Fluor® 488	488 nm	519 nm	FC, ICC, IHC	RUO
65-0865	Fixable Viability Dye eFluor® 780			FC	GPR
88-8823	Intracellular Fixation & Permeabilization Buffer (plus Brefeldin A) (previously named IC Fixation & Permeabilization Buffer)			FC	GPR

References

References: Cho D, Lee WJ, Halloran PJ, Trinchieri G, Kim YB. Enhancement of porcine natural killer cell activity by recombinant human and murine IL-12. Cell Immunol. 1996 Aug 25;172(1):29-34.

Aragane Y, Riemann H, Bhardwaj RS, Schwarz A, Sawada Y, Yamada H, Luger TA, Kubin M, Trinchieri G, Schwarz T. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 1994 Dec 15;153(12):5366-72.

View More Products

Antigens	Area of Biology	Cell Type	Formats
IL-12/IL-23	Cell Cycle & Proliferation	Dendritic Cells Th1 Cells	Alexa Fluor 488