Anti-Mouse IL-10 Biotin

Also known as: Interleukin-10

Clone: JES5-2A5

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 13-7102

Cat. No. Size
13-7102-81 50 ug
13-7102-85 500 ug

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Data for Anti-Mouse IL-10 Biotin.

Description

Description: The JES5-2A5 antibody reacts with mouse interleukin-10 (IL-10). The JES5-2A5 antibody is a neutralizing antibody. Mouse IL-10 is an 18 kDa factor also known as Cytokine Synthesis Inhibitory Factor (CSIF). In the mouse, Th2 cells, B1 cells, macrophages, and keratinocytes are the major cell subsets that produce IL-10. IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response.

Details
Host Rat
Isotype IgG1, kappa
Reactivity Mouse
Conjugate Biotin
Reported Applications ELISA Detection Antibody, ELISPOT Detection Antibody
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
16-7102 Anti-Mouse IL-10 Functional Grade Purified FA RUO
References

References: Tsuboi Y, Abe H, Nakagawa R, Oomizu S, Watanabe K, Nishi N, Nakamura T, Yamauchi A, Hirashima M. Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. Clin Immunol. 2007 Aug;124(2):221-33. (JES5-2A5, NU in vivo, PubMed)

Vasu C, Gorla SR, Prabhakar BS, Holterman MJ. Targeted engagement of CTLA-4 prevents autoimmune thyroiditis. Int Immunol. 2003 May;15(5):641-54. (JES5-2A5, NU in vitro, PubMed)

Sander B, Höidén I, Andersson U, Möller E, Abrams JS. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods. 1993 Dec 3;166(2):201-14.

Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev. 1992 Jun;127:5-24.