Mouse IGF-1 Recombinant Protein

Description: Insulin-like growth factor I (IGF-1), also known as somatomedin C, is a member of the insulin-like growth factor family. This protein is expressed in many cell types and is secreted into the blood. Metabolism of glucose, fatty acids, cartilage and bone, as well as growth hormone activity, are all regulated by IGF-1. This protein also plays important roles in Alzheimer's disease and tumor pathogenesis. IGF-1 and IGF-2 share 70% sequence identity. Furthermore, mature mouse IGF–1 shares 94% and 99% amino acid sequence identity with human and rat IGF–1, respectively, and exhibits cross-species activity. Recombinant mouse IGF-1 produced in E.coli is a single, non-glycosylated, polypeptide containing 70 amino acids.

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Harman, S. M. Metter, E. J. Blackman, M. R. Landis, P. K. Carter, H. B. : Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer. J. Clin. Endocr. Metab. 2002; 85: 4258-4265.

Hankinson, S. E. Willett, W. C. Colditz, G. A. Hunter, D. J. Michaud, D. S. Deroo, B. Rosner, B. Speizer, F. E. Pollak, M. : Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998; 351: 1393-1396.

Lembo, G. Rockman, H. A. Hunter, J. J. Steinmetz, H. Koch, W. J. Ma, L. Printz, M. P. Ross, J., Jr. Chien, K. R. Powell-Braxton, L. : Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J. Clin. Invest.1996; 98: 2648-2655.