Anti-Mouse H-Y TCR (male antigen) FITC

Description: The T3.70 monoclonal antibody reacts with the transgenic αβTCR that recognizes the male antigen H-Y in the context of H-2D^b. A large fraction of T cells in H-Y TCR transgenic mouse expresses this receptor. The H-Y TCR transgenic mouse has been used extensively to study T cell development and the role of thymic major histocompatibility complex in CD4⁺ and CD8⁺ T cell differentiation.

References:
Teh, H. S., H. Kishi, et al. (1990). "Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice." Dev Immunol 1(1): 1-10.
Teh, H. S., H. Kishi, et al. (1989). "Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules." J Exp Med 169(3): 795-806.
Teh, H. S., P. Kisielow, et al. (1988). "Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells." Nature 335(6187): 229-33.