Anti-Mouse gamma delta TCR Purified

Description: The UC7-13D5 monoclonal antibody reacts with the mouse γδ TCR complex. γδ TCR is expressed by a small subset of T cells in the thymus, peripheral lymphoid tissues, intestinal epithelium, and epidermis. The exact specificity, ligand and function of γδ TCR-bearing T cells are not yet fully understood; it is suggested that these cells recognize bacterial ligands and some tumor cells in the context of MHC class I-like gene products and play a role in regulation of the immune response and during bacterial infection.

References: Koenecke C, Chennupati V, Schmitz S, Malissen B, Förster R, Prinz I. In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells. Eur J Immunol. 2009 Feb;39(2):372-9. (UC7-13D5, FA, PubMed)

Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T, Yoshikai Y. A protective role of gamma delta T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology. 1995 Oct;86(2):199-205. (UC7-13D5, FA)

Taguchi, T., W. K. Aicher, et al. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol 1991 147(11): 3736-44.

Kakkanaiah, V. N., M. Nagarkatti, et al. CD4-CD8- thymocytes from MRL-lpr/lpr mice exhibit abnormal proportions of alpha beta- and gamma delta-TCR+ cells and demonstrate defective responsiveness when activated through the TCR. Cell Immunol 1991 137(2): 269-82.

Bluestone, J. A., R. Q. Cron, et al. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev 1991 120: 5-33.