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Anti-Human/Mouse Galectin-3 Purified

Also known as: MAC2

Clone: eBioM3/38 (M3/38)

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 14-5301

Cat. No. Size
14-5301-81 50 ug
14-5301-82 100 ug
14-5301-85 500 ug

Data for Anti-Human/Mouse Galectin-3 Purified.

Staining of mouse thioglycolate-induced peritoneal exudate cells (PECs) with 0.25 ug of Rat IgG2a K...View More

  • Data for Anti-Human/Mouse Galectin-3 Purified.
Description

Description: The eBioM3/38 antibody reacts with mouse Galectin-3 (Mac-2). Galectins are a family of animal lectins which appear to exhibit a variety of biological functions. Galectin 3 (aka LGALS3, galactose-specific soluble lectin 3, Mac-2, L-29) is one of the more extensively studied members of this family and is a 30 kDa beta-galactoside-binding protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homo-oligomerized. Galectin 3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.

This monoclonal antibody eBioM3/38 crossreacts to human Galectin-3 (LGALS3).

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate Purified
Reported Applications Flow Cytometric Analysis, ELISA, Immunohistochemical Staining of Frozen Tissue Sections, Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections, Immunoprecipitation, Western Blotting
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
12-5301 Anti-Human/Mouse Galectin-3 PE 488 - 561 nm 578 nm FC RUO
13-5301 Anti-Human/Mouse Galectin-3 Biotin FC RUO
50-5301 Anti-Human/Mouse Galectin-3 eFluor® 660 633 - 647 nm 668 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
11-4317 Streptavidin FITC 488 nm 520 nm FC, ICC, IHC-F RUO
14-4321 Rat IgG2a K Isotype Control Purified FC, ICC, IHC RUO
13-4813 Anti-Rat IgG Biotin FC, ELISA, IHC, IHC-F, WB RUO
17-4317 Streptavidin APC 633 - 647 nm 660 nm FC RUO
References

References: Oliveira FL, Fraza P, Chammas R, Hsu DK, Liu FT, Borojevic R, Takiya CM, El-Cheikh MC, Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3-/- mice J.J Leukoc Biol. 2007 Aug;82(2):300-10.

Joo G-H, Goedegebuure PS, Sadanaga N, Nagoshi M, von Bernstorff W, Eberlein TJ. Expression and function of galectin-3, a b-galactoside-binding protein in activated T lymphocytesJ Leukoc Biol. 2001 Apr;69(4):555-64.

Ho MK, Springer TA. MAC-2, A Novel 32000 Mr Mouse Macrophage Subpopulation-Specific Antigen Defined by Monoclonal Antibodies. J Immunol. 1982 Mar;128(3):1221-8.