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Anti-Human/Mouse Galectin-3 Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-5301)

Also known as: MAC2

Clone: eBioM3/38 (M3/38)

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-5301

Cat. No. Size
51-5301-80 25 ug
51-5301-82 100 ug
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Data for Anti-Human/Mouse Galectin-3 Alexa Fluor® 647.

Staining of mouse thioglycolate-induced peritoneal exudate cells (PECs) with Anti-Mouse CD11b PE...View More

  • Data for Anti-Human/Mouse Galectin-3 Alexa Fluor® 647.
Description

Description: The eBioM3/38 antibody reacts with mouse Galectin-3 (Mac-2). Galectins are a family of animal lectins which appear to exhibit a variety of biological functions. Galectin 3 (aka LGALS3, galactose-specific soluble lectin 3, Mac-2, L-29) is one of the more extensively studied members of this family and is a 30 kDa beta-galactoside-binding protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homo-oligomerized. Galectin 3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.

This monoclonal antibody eBioM3/38 crossreacts to human Galectin-3 (LGALS3).

Details
Host Rat
Isotype IgG2a, kappa
Reactivity Mouse
Conjugate Alexa Fluor 647
Laser Red Laser
Emit 668 nm
Excite 633 nm
Legal Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
13-5301 Anti-Human/Mouse Galectin-3 Biotin FC RUO
12-5301 Anti-Human/Mouse Galectin-3 PE 488 - 561 nm 575 nm FC RUO
14-5301 Anti-Human/Mouse Galectin-3 Purified FC, ELISA, IHC, IP, WB RUO
50-5301 Anti-Human/Mouse Galectin-3 eFluor® 660 (Alexa Fluor® 647 Replacement) 633 nm 668 nm FC RUO
References

References: Ho MK, Springer TA. 1982. MAC-2, A Novel 32000 Mr Mouse Macrophage Subpopulation-Specific Antigen Defined by Monoclonal Antibodies. J. Immunol. 128(3):1221-1228.

Joo G-H, Goedegebuure PS, Sadanaga N, Nagoshi M, von Bernstorff W, Eberlein TJ. Expression and function of galectin-3, a b-galactoside-binding protein in activated T lymphocytes J. Leukoc. Biol. 69: 555–564; 2001.

Oliveira FL, Fraza P, Chammas R, Hsu DK, Liu FT, Borojevic R, Takiya CM, El-Cheikh MC, Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3-/- mice J. Leukoc. Biol. 82: ePub; 2007

Springer TA, 1981. Monoclonal Antibody Analysis of Complex Biological Systems. J. Biol Chem. 256(8):3833-3839.

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