Anti-Mouse Fc epsilon Receptor I alpha (FceR1) Alexa Fluor® 647 (To Be Discontinued; See Alternative Format: APC cat. 17-5898)

Also known as: high affinity IgE receptor

Clone: MAR-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Discontinued. Refer to Replacement Format APC cat. 17-5898

SKU# 51-5898

Cat. No.	Size
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Description

Description: The MAR-1 monoclonal antibody reacts with the Fc epsilon Receptor I alpha subunit, an IgE-binding subunit lacking signal-transducing ability. Fc epsilon RI alpha; is expressed on mast and basophil cells and is up-regulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions.

Details

Host	Armenian Hamster
Isotype	IgG
Reactivity	Mouse
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis

Documentation

For complete product information, please download the TDS or IFU document.

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) Purified			FC, IHC, FA, IP	RUO
16-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) Functional Grade Purified			FC, FA	RUO
13-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) Biotin			FC	RUO
17-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) APC	633 nm	660 nm	FC	RUO
11-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) FITC	488 nm	518 nm	FC	RUO
12-5898	Anti-Mouse Fc epsilon Receptor I alpha (FceR1) PE	488 nm	575 nm	FC	RUO

References

References: Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008 Mar;9(3):310-8.(MAR-1, FA, PubMed)

Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H. Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007 Aug 1;110(3):913-20. (MAR-1, FC)

Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18105-10. (MAR-1, FC, PubMed)

Yamaguchi M., K. Hirai, A. Komiya, M. Miyamasu, Y. Furumoto, R. Teshima, K. Ohta, Y. Morita, S. J. Galli, C. Ra, K. Yamamoto. Regulation of Mouse Mast Cell Surface Fc epsilon RI expression by dexamethasone. Int Immunol 2001. 13(7):843-51.

View More Products

Antigens	Area of Biology	Cell Type	Formats
Fc Epsilon Receptor 1 alpha (FceRI)	Innate Immunity	Macrophage & Monocyte Cells	Alexa Fluor 647