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Mouse EGF Recombinant Protein (Discontinued)

Also known as: epidermal growth factor

RUO: For Research Use Only. Not for use in diagnostic procedures.

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SKU# 14-8984

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Data for Mouse EGF Recombinant Protein.

Standard curve of Mouse EGF Recombinant Protein. ...View More

  • Data for Mouse EGF Recombinant Protein.

Description: Epidermal growth factor (EGF) is the member of the EGF family that shares a structural motif, the EGF-like domain, and are synthesized as type I transmembrane precursor proteins that contain several EGF domains in the extracellular region. The mouse EGF precursor has 1217 amino acid residues containing nine EGF domains. The mature protein consists of 53 aa and is generated by proteolytic excision of the EGF domain proximal to the transmembrane region resulting in a molecular mass of 6 kDa. EGF is produced by many cell types and in blood and various body fluids, including milk, urine, saliva, seminal fluid, pancreatic juice, cerebrospinal fluid, and amniotic fluid. EGF can promote proliferation and differentiation of mesenchymal and epithelial cells. EGF is also a mitogen for fibroblasts, epithelial and endothelial cells, and promotes colony formation of epiderma.

Reactivity Mouse
Purity > 97%, as determined by SDS-PAGE
Endotoxin Level Less than 0.1 ng/ug cytokine as determined by the LAL assay.
Reported Applications Cytokine Bioassays
TDS Link Download TDS

References: Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA. 2008 Jan 2;299(1):53-60.

Chan SY, Wong RW. Expression of epidermal growth factor in transgenic mice causes growth retardation. J Biol Chem. 2000 Dec 8;275(49):38693-8.

Zabel BU, Eddy RL, Lalley PA, Scott J, Bell GI, Shows TB. Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the beta subunit of nerve growth factor. Proc Natl Acad Sci U S A. 1985 Jan;82(2):469-73.