Anti-Mouse DO11.10 TCR APC

Description: The KJ1-26 anti-idiotypic monoclonal antibody binds theT-cell receptor (TCR) expressed on DO11.10 and DO11.10.24 murine T cellhybridomas, but not on any other T cell hybridomas tested.The TCR expressedon DO11.10 recognizes an ovalbumin peptide in the context of I-A^d majorhistocompatibility molecules.The use of DO11.10 and KJ1-26 have proven tobe instrumental in describing many of the intricate details of T cellimmunity.

References: Haskins, K., R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack.1983. The major histocompatibility complex-restricted antigen receptor onT cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157: 1149-69.

Marrack, P., R. Shimonkevitz, C. Hannum, K. Haskins, and J. Kappler.1983. The major histocompatibility complex-restricted antigen receptor onT cells. IV. An anti-idiotypic antibody predicts both antigen and Ispecificity.J. Exp. Med. 158: 1635-46.

Murphy, K. M., A. B. Heimberger, and D. Y. Loh. 1990. Induction byantigen of intrathymic apoptosis of CD4+ CD8+ TCR lo thymocytes in vivo.Science. 250: 1720-3.