Anti-Mouse CXCL9 (MIG) eFluor® 660 (Alexa Fluor® 647 Replacement)

Description: The monoclonal antibody MIG-2F5.5 reacts with mouse monokine induced by IFN gamma (mig, mig-1, CXCL9). This 14.4 kDa inflammatory chemokine is specifically induced by IFN gamma, but not other activators such as LPS or IFN alpha. Secretion of mig, mainly by macrophages results in the chemotaxis of a variety of activated T cells via the CXCR3 chemokine receptor. Mig is involved many areas of research including autoimmune diseases, cancer, and inflammation.

References: Lu H, Yu M, Sun Y, Mao W, Wang Q, Wu M, Han W. Expression and purification of bioactive high-purity mouse monokine induced by IFN-gamma in Escherichia coli.Protein Expr Purif. 2007 Sep;55(1):132-8.

Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K, Akdis CA. A Second Step of Chemotaxis After Transendothelial Migration: Keratinocytes Undergoing Apoptosis Release IFN-gamma-Inducible Protein 10, Monokine Induced by IFN-gamma, and IFN-gamma-Inducible alpha-Chemoattractant for T Cell Chemotaxis Toward Epidermis in Atopic Dermatitis. J Immunol. 2003 Jul 15;171(2):1078-84.

Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P, Farber JM. Human Mig chemokine: biochemical and functional characterization. J Exp Med. 1995 Nov 1;182(5):1301-14.

Wong P, Severns CW, Guyer NB, Wright TM. A unique palindromic element mediates gamma interferon induction of mig gene expression. Mol Cell Biol. 1994 Feb;14(2):914-22.