Mouse CXCL10 (IP-10) Recombinant Protein

Description: IP-10, or Interferon Gamma Inducible Protein 10, is a CXC chemokine also known as CXCL10. IP-10 is induced in monocytes, fibroblasts, and endothelial cells by IFNγ. It is also induced by LPS, IL-1β, TNF-α, IL-12, and viral infection. IP-10 is a chemoattractant for CXCR3+ T cells, which plays an important role in Th1-type inflammatory diseases, as well as several endocrine-related autoimmune diseases such as Hashimoto's thyroiditis. Recombinant mouse IP-10 produced in E.Coli is a single, non-glycosylated polypeptide containing 77 amino acids with a molecular mass of 8.5 kDa.

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Rhode, A. Pauza, M. E. Barral, A. M. Rodrigo, E. Oldstone, M. B. A. von Herrath, M. G. Christen, U. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. J Immunol. 2005 Sep 15;175(6):3516-24.

Booth, V. Keizer, D. W. Kamphuis, M. B. Clark-Lewis, I. Sykes, B. D. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 2002 Aug 20;41(33):10418-25.

Dufour, J. H. Dziejman, M. Liu, M. T. Leung, J. H. Lane, T. E. Luster, A. D. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 1;168(7):3195-204.