Anti-Mouse CMKLR1 PE

Description: The 194.7.4 (BZ194)monoclonal antibody reacts to mouse Chemoattractant-like receptor 1 (CMKLR1), also known as ChemR23 and DEZ. CMKLR1 is the receptor for chemerin, a potent chemoattractant. The BZ194 antibody was generated against the amino terminal residues of mouse CMKLR1. In the human CMKLR is found on pDC while in the mouse expression is confined to resident peritoneal macrophages with highest expression on Cd11b^lo macrophages. Expression is absent on in vitro cultured bone marrow DCs (except on early DCs as defined by CD11c⁺MHCII^int), and on freshly isolated CD11c+ cells from lymph node, spleen and bone marrow. Mouse CMKLR is thought to play a role in macrophage function as a result of injury.

References: Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC.Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands.Exp Hematol. 2006 Aug;34(8):1106-14. (BZ194, FC, PubMed)