Mouse Chemerin Recombinant Protein Carrier-Free

Also known as: tazarotene-induced gene 2 TIG2, retinoic acid receptor responder 2 RARRES2

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 34-8951

Cat. No. Size
34-8951-82 100 ug

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Data for Mouse Chemerin Recombinant Protein Carrier-Free.

Description

Description: Chemerin is a potent chemoattractant, identified as the ligand of CMKLR (also known as Chem23R, DEZ), a receptor expressed by plasmacytoid DCs, and some macrophage and NK cell subsets. Pro-chemerin circulates in the blood and is biologically inactive, until processed by a variety of serine proteases at sites of tissue damage to remove six C-terminal amino acid residues. The cleaved, mature form of chemerin is biologically active and recruits CMKLR1-positive cells to sites of tissue damage. Chemerin is a member of the cystatin superfamily and contains three intrachain disulfide bonds.

Details
Reactivity Mouse
Purity Greater than 98%, as determined by SDS-PAGE.
Molecular Mass Mature mouse chemerin protein has a predicted molecular mass of approximately 16,000 kDa.
Reported Applications Cytokine Bioassays
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
14-8951 Mouse Chemerin Recombinant Protein FA RUO
References

References: Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brezillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med. 2003 Oct 6;198(7):977-85. (PubMed)

Zabel BA, Silverio AM, Butcher EC. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J Immunol. 2005 Jan 1;174(1):244-51. (PubMed)

Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, Butcher EC. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem. 2005 Oct 14;280(41):34661-6. (PubMed)

Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp Hematol. 2006 Aug;34(8):1106-14. (PubMed)