Anti-Mouse CD94 Purified

Description: The 18d3 monoclonal antibody reacts with mouse CD94, a 70 kDa type II transmembrane glycoprotein. CD94 belongs to the C-type lectin superfamily and is present as a heterodimer with NKG2 on the surface. CD94 is expressed by NK cells, a subset of T cells, and NKT cells and plays an important role in adhesion and activation of NK cell lineage. DBA/2J mice are naturally CD94-deficient and do not express cell-surface CD94/NKG2A receptors, even on neonatal NK cells.

References:
Vance, R. E., A. M. Jamieson, et al. (1999). "Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells." J Exp Med 190(12): 1801-12.
Vance, R. E., J. R. Kraft, et al. (1998). "Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)." J Exp Med 188(10): 1841-8.
Vance, R. E., D. M. Tanamachi, et al. (1997). "Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells." Eur J Immunol 27(12): 3236-41.