Anti-Mouse CD84 APC

Description: This mCD84.7 monoclonal antibody reacts with mouse CD84, a 64- to 82-kDa member of the SLAM family of Ig receptors. CD84 is a highly glycosylated single transmembrane receptor. Expressed in B and T cells, monocytes, platelets, and thymocytes, this receptor was recently found to also be expressed on Sca-1⁺c-kit⁺Lin^- mouse bone marrow hematopoietic stem cells. CD84 has been reported to bind itself homophilically to promote IFNγ secretion and act as a costimulatory molecule. Once phosphorylated, the cytoplasmic tail binds signaling lymphocyte activation molecule-associated protein (SAP).

References: Sintes J, Romero X, Marin P, Terhorst C, Engel P. Differential expression of CD150 (SLAM) family receptors by human hematopoietic stem and progenitor cells. Exp Hematol. 2008 Sep;36(9):1199-204.

Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P. CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J Immunol. 2005 Jun 1;174(11):7033-42. (mCD84.7, FC,Pubmed)

Martin M, Romero X, de la Fuente MA, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P. CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1. J Immunol. 2001 Oct 1;167(7):3668-76.