Anti-Mouse CD80 (B7-1) PE-Cyanine5

Also known as: B71, Ly-53

Clone: 16-10A1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 15-0801

Cat. No. Size
15-0801-81 50 ug
15-0801-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Mouse CD80 (B7-1) PE-Cy5.

Staining of 3-day LPS activated C57Bl/6 splenocytes with 0.03 ug of Armenian Hamster IgG Isotype...View More

  • Data for Anti-Mouse CD80 (B7-1) PE-Cy5.
Description

Description: The 16-10A1 monoclonal antibody reacts with mouse CD80 (B7-1), a 55 kDa member of the Ig superfamily. CD80 is expressed by macrophages, dendritic cells and activated B cells. In addition, activated T cells express this antigen. CD80 has high affinity for binding to two T cell surface antigens, CD28 and CD152 (CTLA-4). The interaction of CD28 and CD152 with CD80 is crucial in T-B cell communication leading to activation of T and B cells, respectively.

Details
Host Armenian Hamster
Isotype IgG
Reactivity Canine, Mouse, Pig
Conjugate PE-Cyanine5
Laser Blue Laser, Green Laser, Yellow-Green Laser
Excite 488 - 561 nm
Legal FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications Flow Cytometric Analysis
Documentation
TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
13-0801 Anti-Mouse CD80 (B7-1) Biotin FC RUO
12-0801 Anti-Mouse CD80 (B7-1) PE 488 - 561 nm FC RUO
14-0801 Anti-Mouse CD80 (B7-1) Purified FC, IHC, FA, IP RUO
17-0801 Anti-Mouse CD80 (B7-1) APC 633 - 647 nm 660 nm FC RUO
16-0801 Anti-Mouse CD80 (B7-1) Functional Grade Purified FC, FA RUO
11-0801 Anti-Mouse CD80 (B7-1) FITC 488 nm FC RUO
Related Products
Cat. No. Name Excite Emit Application Reg.
15-4888 Armenian Hamster IgG Isotype Control PE-Cyanine5 488 - 561 nm FC RUO
References

References: Zhang B, Wang Z, Ding J, Peterson P, Gunning WT, Ding HF. NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. J Biol Chem. 2006 Dec 15;281(50):38617-24. (16-10A1, IHC frozen)

Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR. Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J Am Soc Nephrol. 2005 Jul;16(7):2012-22. (16-10A1, FA and IHC frozen)

Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13967-72. (16-10A1, IHC frozen)

Razi-Wolf Z, Falo LD Jr, Reiser H. Expression and function of the costimulatory molecule B7 on murine Langerhans cells: evidence for an alternative CTLA-4 ligand. Eur J Immunol. 1994 Apr;24(4):805-11.

Galvin F, Freeman GJ, Razi-Wolf Z, Hall W Jr, Benacerraf B, Nadler L, Reiser H. Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol. 1992 Dec 15;149(12):3802-8.

Razi-Wolf Z, Freeman GJ, Galvin F, Benacerraf B, Nadler L, Reiser H. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4210-4.