Anti-Mouse CD70 Functional Grade Purified

Description: The FR70 monoclonal antibody reacts with mouse CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

References: Oshima, H., H. Nakano, et al. (1998). Characterization of murine CD70 by molecular cloning and mAb. Int Immunol 10(4): 517-26.

Akiba, H., H. Oshima, et al. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J Immunol 162(12): 7058-66.