Anti-Mouse CD54 (ICAM-1) Functional Grade Purified

Description: The YN1/1.7.4 monoclonal antibody reacts with mouse CD54 (InterCellular Adhesion Molecule-1, ICAM-1), a 90-110 kDa transmembrane glycoprotein expressed by monocytes, lymphocytes, dendritic cells, and endothelial cells. Expression of CD54 is upregulated on activated lymphocytes. Interaction of CD54 with its ligands CD11a and CD11b is important in the inflammatory response. The YN1/1.7.4 monoclonal antibody recognizes a different epitope than the eBioKAT-1 monclonal antibody.

References:
Burns, A. R., F. Takei, et al. (1994). "Quantitation of ICAM-1 expression in mouse lung during pneumonia." J Immunol 153(7): 3189-98.
Fabry, Z., M. M. Waldschmidt, et al. (1992). "Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55." J Neuroimmunol 36(1): 1-11.
Jevnikar, A. M., R. P. Wuthrich, et al. (1990). "Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells." Kidney Int 38(3): 417-25.
Kumasaka, T., W. M. Quinlan, et al. (1996). "Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice." J Clin Invest 97(10): 2362-9.