Anti-Mouse CD51 (Integrin alpha V) Biotin

Description: The RMV-7 monoclonal antibody reacts with the mouse CD51 molecule, the integrin alpha v chain. This approximately 120 kDa surface molecule non-covalently associates with the β subunits of the integrin family including β₃ (CD61), β₁ (CD29), β₅ and β₆ to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by platelets, T cells and granulocytes and mediate adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.

References:
Tsujimura, K., T. Takahashi, et al. (1998). "Two types of anti-TL (thymus leukemia) CTL clones with distinct target specificities: differences in cytotoxic mechanisms and accessory molecule requirements." J Immunol 160(11): 5253-61.
Takahashi, K., T. Nakamura, et al. (1991). "Antigen-independent T cell activation mediated by a very late activation antigen-like extracellular matrix receptor." Eur J Immunol 21(6): 1559-62.
Takahashi, K., T. Nakamura, M. Koyanagi, K. Kato, Y. Hashimoto, H. Yagita, and K. Okumura. 1990. A murine very late activation antigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-target cell interaction. J. Immunol. 145:4371-4379