Anti-Mouse CD49d (Integrin alpha 4) Purified

Also known as: Integrin a4, VLA4, ITGA4

Clone: R1-2

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 14-0492

Cat. No.	Size
14-0492-81	50 ug
14-0492-82	100 ug
14-0492-85	500 ug
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Staining of mouse splenocytes with Anti-Mouse CD49d PE. Appropriate isotype controls were used ...View More

Description

Description: The R1-2 monoclonal antibody reacts with mouse CD49d, the 150 kDa integrin alpha4 subunit. The complex of CD49d non-covalently associated with integrin beta1 (CD29), also known as VLA-4, is a receptor for fibronectin and VCAM-1 (CD106). This complex is expressed by thymocytes, peripheral lymphocytes, monocytes and eosinophils. CD49d also associates with integrin b7 and binds to the Mucosal vascular Addressin (MAdCAM-1).

Details

Host	Rat
Isotype	IgG2b, kappa
Reactivity	Mouse
Conjugate	Purified
Reported Applications	Flow Cytometric Analysis, Immunohistochemical Staining, Functional Assays, Immunoprecipitation

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
11-0492	Anti-Mouse CD49d (Integrin alpha 4) FITC	488 nm	518 nm	FC	RUO
13-0492	Anti-Mouse CD49d (Integrin alpha 4) Biotin			FC	RUO
16-0492	Anti-Mouse CD49d (Integrin alpha 4) Functional Grade Purified			FC	RUO
12-0492	Anti-Mouse CD49d (Integrin alpha 4) PE	488 - 561 nm	575 nm	FC	RUO
46-0492	Anti-Mouse CD49d (Integrin alpha 4) PerCP-eFluor® 710	488 nm	710 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
11-4317	Streptavidin FITC	488 nm		FC, ICC, IHC	RUO
11-4811	Anti-Rat IgG FITC	488 nm		FC, ICC, IHC	RUO
12-4317	Streptavidin PE	488 - 561 nm		FC	RUO
13-4813	Anti-Rat IgG Biotin			FC, ELISA, IHC, WB	RUO
14-4031	Rat IgG2b K Isotype Control Purified			FC, ICC, IHC	RUO
17-4317	Streptavidin APC	633 - 647 nm	660 nm	FC	RUO

References

References: Holzmann B, McIntyre BW, Weissman IL. Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell. 1989 Jan 13;56(1):37-4.

Neuhaus H, Hu MC, Hemler ME, Takada Y, Holzmann B, Weissman IL. Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. J Cell Biol. 1991 Nov;115(4):1149-58.

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Antigens	Area of Biology	Cell Type	Formats
CD49d (Integrin alpha 4)	Adaptive Immunity Adhesion & Migration Cell Signaling Angiogenesis	B Cells Dendritic Cells Macrophage & Monocyte Cells T Cells	Purified