Anti-Mouse CD49d (Integrin alpha 4) Biotin

Description: The R1-2 monoclonal antibody reacts with mouse CD49d, the 150 kDa integrin α₄ subunit. The complex of CD49d non-covalently associated with integrin β₁ (CD29), also known as VLA-4, is a receptor for fibronectin and VCAM-1 (CD106). This complex is expressed by thymocytes, peripheral lymphocytes, monocytes and eosinophils. CD49d also associates with integrin b7 and binds to the Mucosal vascular ADdressin (MAdCAM-1).

References:
Holzmann, B., B. W. McIntyre, et al. (1989). "Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha." Cell 56(1): 37-46.
Neuhaus, H., M. C. Hu, et al. (1991). "Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule." J Cell Biol 115(4): 1149-58.