Anti-Mouse CD49b (Integrin alpha 2) PE

Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5⁺PK136^- and DX5^-PK136⁺ cells.

References:
Hussell, T. and P. J. Openshaw (1998). "Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection." J Gen Virol 79(Pt 11): 2593-601.
Vos, Q., J. R. Ortaldo, et al. (1998). "Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro." Int Immunol 10(8): 1093-101.
Arase, H., T. Saito, et al. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (alpha(2) integrin, very late antigen-2). J Immunol 167(3): 1141-4.