Anti-Mouse CD49b (Integrin alpha 2) PE-Cyanine7

Also known as: ITGA2, DX5, pan-NK

Clone: DX5

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-5971

Cat. No.	Size
25-5971-81	50 ug
25-5971-82	100 ug
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Staining of C57BL/6 splenocytes with Anti-Mouse NK1.1 FITC (cat. 11-5941) and staining buffer...View More

Description

Description: The DX5 monoclonal antibody reacts with CD49b, an antigen expressed on a majority of mouse natural killer cells and a subset of T cells. DX5 reacts with all strains of mouse tested including the most commonly used strains, BALB/c, C57BL/6, C3H, CBA, DBA, AKR, SJL and 129. Simultaneous staining of C57BL/6 spleen cells with anti-NK1.1 mAb (PK136) and DX5 reveals coexpression of both markers by a majority of cells as well as presence of small populations of DX5+PK136- and DX5-PK136+ cells.

Details

Host	Rat
Isotype	IgM, kappa
Reactivity	Mouse
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
14-5971	Anti-Mouse CD49b (Integrin alpha 2) Purified			FC	RUO
48-5971	Anti-Mouse CD49b (Integrin alpha 2) eFluor® 450	405 nm	450 nm	FC	RUO
12-5971	Anti-Mouse CD49b (Integrin alpha 2) PE	488 - 561 nm	575 nm	FC	RUO
17-5971	Anti-Mouse CD49b (Integrin alpha 2) APC	633 - 647 nm	660 nm	FC	RUO
36-5971	Anti-Mouse CD49b (Integrin alpha 2) Functional Grade Biotin			FC	RUO
15-5971	Anti-Mouse CD49b (Integrin alpha 2) PE-Cyanine5	488 - 561 nm		FC	RUO
13-5971	Anti-Mouse CD49b (Integrin alpha 2) Biotin			FC	RUO
47-5971	Anti-Mouse CD49b (Integrin alpha 2) APC-eFluor® 780	633 - 647 nm	780 nm	FC	RUO
11-5971	Anti-Mouse CD49b (Integrin alpha 2) FITC	488 nm	518 nm	FC	RUO
46-5971	Anti-Mouse CD49b (Integrin alpha 2) PerCP-eFluor® 710	488 nm	710 nm	FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
11-5941	Anti-Mouse NK1.1 FITC	488 nm	518 nm	FC	RUO

References

References: Arase H, Saito T, Phillips JH, Lanier LL. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol. 2001 Aug 1;167(3):1141-4.

Hussell T, Openshaw PJ. Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection. J Gen Virol. 1998 Nov;79 ( Pt 11):2593-601.

Vos Q, Ortaldo JR, Conan-Cibotti M, Vos MD, Young HA, Anderson SK, Witherspoon K, Prager I, Snapper CM, Mond JJ. Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro. Int Immunol. 1998 Aug;10(8):1093-101.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD49b (Integrin alpha 2)	Adaptive Immunity Adhesion & Migration Cell Signaling Angiogenesis	Macrophage & Monocyte Cells NK & NKT Cells T Cells	PE-Cyanine7