Anti-Mouse CD40 APC

Description: The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

References:
Ferlin, W. G., T. von der Weid, et al. (1998). "The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb." Eur J Immunol 28(2): 525-31.
Ferlin, W. G., E. Severinson, et al. (1996). "CD40 signaling induces interleukin-4-independent IgE switching in vivo." Eur J Immunol 26(12): 2911-5.
Heath, A. W., W. W. Wu, et al. (1994). "Monoclonal antibodies to murine CD40 define two distinct functional epitopes." Eur J Immunol 24(8): 1828-34.