Anti-Mouse CD40 APC

Description: The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

References: Ferlin WG, von der Weid T, Cottrez F, Ferrick DA, Coffman RL, Howard MC. The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb. Eur J Immunol. 1998 Feb;28(2):525-31.

Ferlin WG, Severinson E, Ström L, Heath AW, Coffman RL, Ferrick DA, Howard MC. CD40 signaling induces interleukin-4-independent IgE switching in vivo. Eur J Immunol. 1996 Dec;26(12):2911-5.

Heath AW, Wu WW, Howard MC. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol. 1994 Aug;24(8):1828-34..