Anti-Mouse CD4 Biotin

Description: The RM4-4 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by the majority of thymocytes, a subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with the protein tyrosine kinase lck through its cytoplasmic tail. Binding of RM4-4 does not block binding of the CD4 monoclonal antibodies RM4-5 or GK1.5.

References: Godfrey, D.I., J. Kennedy, P. Mombaerts, S. Tonegawa, and A. Zlotnik. Onset of TCR-gene rearrangement and role of TCR-expression during CD3-CD4-CD8- thymocyte differentiation. J. Immunol 1994. 152: 4783 - 4792.

Wu, L., R. Scollay, M. Egerton, M. Pearse, G.J. Spangrude, and K. Shortman. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 1991. 349: 71 - 74.

Wu, L., M. Antica, G.R. Johnson, R. Scollay, and K. Shortman. Developmental potential of the earliest precursor cells from the adult mouse thymus. J. Exp. Med.1991. 174: 1617 - 1627.

Fredrickson, G.G., and R.S. Basch. L3T4 antigen expression by hemopoietic precursor cells. J. Exp. Med.1989. 169: 1473 - 1478.