Anti-Mouse CD38 APC

Description: The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42 kDa type II transmembrane protein. CD38 is expressed at increasingly higher levels on B cells at each stage of B-cell differentiation, and is then down-regulated on germinal center B cells and mature plasma cells. Its expression is reported on a subpopulation of thymocytes, mature T cells, and NK cells. Crosslinking of CD38 on the surface of mature, resting B cells induces B-cell proliferation, which is enhanced by co-signals such as IL-4 and LPS. CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a role in lymphocyte activation and differentiation.

References: Oliver, A. M., J. C. Grimaldi, et al. 1999. Independently ligating CD38 and Fc gammaRIIB relays a dominant negative signal to B cells. Hybridoma 18(2): 113-9.

Oliver, A. M., F. Martin, et al. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur J Immunol 27(9): 2366-74.

Oliver, A. M., F. Martin, et al. 1997. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol 158(3): 1108-15.