Anti-Mouse CD357 (GITR) PE-Cyanine7

Also known as: TNFRSF18, AITR, glucocorticoid-induced TNFR-related

Clone: DTA-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-5874

Cat. No.	Size
25-5874-80	25 ug
25-5874-82	100 ug
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Staining of C57BL/6 splenocytes with Anti-Mouse CD25 PE (cat. 12-0251) and 0.03 ug of Rat IgG2b K...View More

Description

Description: The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.

Details

Host	Rat
Isotype	IgG2b, kappa
Reactivity	Mouse
Conjugate	PE-Cyanine7
Laser	Blue Laser, Green Laser, Yellow-Green Laser
Emit	775 nm
Excite	488 - 561 nm
Legal	FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
17-5874	Anti-Mouse CD357 (GITR) APC	633 - 647 nm	660 nm	FC	RUO
48-5874	Anti-Mouse CD357 (GITR) eFluor® 450	405 nm		FC	RUO
13-5874	Anti-Mouse CD357 (GITR) Biotin			FC	RUO
12-5874	Anti-Mouse CD357 (GITR) PE	488 - 561 nm		FC	RUO
46-5874	Anti-Mouse CD357 (GITR) PerCP-eFluor® 710	488 nm	710 nm	FC	RUO
11-5874	Anti-Mouse CD357 (GITR) FITC	488 nm		FC	RUO
16-5874	Anti-Mouse CD357 (GITR) Functional Grade Purified			FC, FA	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
12-0251	Anti-Mouse CD25 PE	488 - 561 nm	575 nm	FC	RUO
25-4031	Rat IgG2b K Isotype Control PE-Cyanine7	488 - 561 nm	775 nm	FC	RUO

References

References: Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, Shimizu J, Nomura T, Chiba T, Sakaguchi S. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 2005 Oct 3;202(7):885-91. ( DTA-1, FA)

Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002 Feb;3(2):135-42.

View More Products

Antigens	Area of Biology	Cell Type	Formats
CD357 (GITR)	Adaptive Immunity	T Cells Treg Cells	PE-Cyanine7