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Anti-Mouse CD357 (GITR) PE-Cy7

Also known as: TNFRSF18, AITR

Clone: DTA-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 25-5874

Cat. No. Size
25-5874-80 25 ug
25-5874-82 100 ug
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Data for Anti-Mouse CD357 (GITR) PE-Cy7.

Staining of C57BL/6 splenocytes with Anti-Mouse CD25 PE (cat. 12-0251) and 0.03 ug of Rat IgG2b...View More

  • Data for Anti-Mouse CD357 (GITR) PE-Cy7.
Description

Description: The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR abrogates Treg cell-mediated suppression. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.

Details
Host Rat
Isotype IgG2b
Reactivity Mouse
Conjugate PE-Cy7
Laser Blue Laser
Emit 760 nm
Excite 488 nm
Legal FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT FOR NON-COMMERCIAL RESEARCH USE ONLY. NOT FOR THERAPEUTIC OR IN VIVO APPLICATIONS. OTHER USE NEEDS LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. UNDER U.S. PATENT # 5,268,486, 5,569,587 AND 5,627,027 AND FOREIGN EQUIVALENTS AND PENDING APPLICATIONS. THIS MATERIAL IS SUBJECT TO PROPRIETARY RIGHTS OF GE HEALTHCARE BIO-SCIENCES CORP. AND CARNEGIE MELLON UNIVERSITY AND MADE AND SOLD UNDER LICENSE FROM GE HEALTHCARE BIO-SCIENCES CORP. THIS PRODUCT IS LICENSED FOR SALE ONLY FOR RESEARCH. IT IS NOT LICENSED FOR ANY OTHER USE. THERE IS NO IMPLIED LICENSE HEREUNDER FOR ANY COMMERCIAL USE. COMMERCIAL USE shall include: 1. sale, lease, license or other transfer of the material or any material derived or produced from it; 2. sale, lease, license or other grant of rights to use this Material or any material derived or produced from it; 3. use of this material to perform services for a fee for third parties. IF YOU REQUIRE A COMMERCIAL LICENSE TO USE THIS MATERIAL AND DO NOT HAVE ONE, RETURN THIS MATERIAL, UNOPENED TO EBIOSCIENCE, INC. 10255 SCIENCE CENTER DRIVE, SAN DIEGO, CALIFORNIA 92121 USA AND ANY MONEY PAID FOR THE MATERIAL WILL BE REFUNDED.
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
11-5874 Anti-Mouse CD357 (GITR) FITC 488 nm 518 nm FC RUO
16-5874 Anti-Mouse CD357 (GITR) Functional Grade Purified FC, FA RUO
48-5874 Anti-Mouse CD357 (GITR) eFluor® 450 405 nm 450 nm FC RUO
12-5874 Anti-Mouse CD357 (GITR) PE 488 - 561 nm 575 nm FC RUO
13-5874 Anti-Mouse CD357 (GITR) Biotin FC RUO
17-5874 Anti-Mouse CD357 (GITR) APC 633 - 647 nm 660 nm FC RUO
References

References: Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002 Feb;3(2):135-42.

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