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SKU# 16-5874
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Staining of C57Bl/6 splenocytes with 0.015 ug of Rat IgG2b Isotype Control Purified (cat. 14-4031)...View More
Description: The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR abrogates Treg cell-mediated suppression. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.
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References: Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002 Feb;3(2):135-42.
Anti-Mouse CD357 (GITR) eFluor® 450
Anti-Mouse CD357 (GITR) Biotin
Anti-Mouse CD357 (GITR) APC
Anti-Mouse CD335 (NKp46) PE
Anti-Mouse CD335 (NKp46) FITC
