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Anti-Mouse CD357 (GITR) eFluor® 450

Also known as: TNFRSF18, AITR, glucocorticoid-induced TNFR-related

Clone: DTA-1

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 48-5874

Cat. No. Size
48-5874-80 25 ug
48-5874-82 100 ug
Please inquire about custom configurations or bulk packaging.

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Data for Anti-Mouse CD357 (GITR) eFluor® 450 (Pacific Blue® replacement).

Staining of C57BL/6 splenocytes with Anti-Mouse CD25 PE (cat. 12-0251) and 0.03 ug of Rat IgG2b...View More

  • Data for Anti-Mouse CD357 (GITR) eFluor® 450 (Pacific Blue® replacement).
Description

Description: The DTA-1 monoclonal antibody reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR abrogates Treg cell-mediated suppression. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.

Details
Host Rat
Isotype IgG2b
Reactivity Mouse
Conjugate eFluor 450
Laser Violet Laser
Emit 450 nm
Excite 405 nm
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
13-5874 Anti-Mouse CD357 (GITR) Biotin FC RUO
11-5874 Anti-Mouse CD357 (GITR) FITC 488 nm 518 nm FC RUO
17-5874 Anti-Mouse CD357 (GITR) APC 633 - 647 nm 660 nm FC RUO
12-5874 Anti-Mouse CD357 (GITR) PE 488 - 561 nm 575 nm FC RUO
25-5874 Anti-Mouse CD357 (GITR) PE-Cy7 488 nm 760 nm FC RUO
16-5874 Anti-Mouse CD357 (GITR) Functional Grade Purified FC, FA RUO
References

References: Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002 Feb;3(2):135-42.

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