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  • Anti-Mouse CD317 (BST2, PDCA-1) Alexa Fluor® 647 (Discontinued. Refer to Alternative Format: APC, cat. 17-3172)

Anti-Mouse CD317 (BST2, PDCA-1) Alexa Fluor® 647 (Discontinued. Refer to Alternative Format: APC, cat. 17-3172)

Also known as: plasmacytoid DC Ag-1, pDC Ag-1, BST 2, PDCA1

Clone: eBio927

RUO: For Research Use Only. Not for use in diagnostic procedures.

Attention: Discontinued. Refer to Replacement Format APC, cat. 17-3172

SKU# 51-3172

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Data for Anti-Mouse CD317 (BST2, PDCA-1) Alexa Fluor® 647 (To Be Discontinued. Refer to Alternative Format: APC, cat. 17-3172).

Staining of SJL splenocytes with Anti-Mouse CD11c PE (cat. 12-0114) (left) or Anti-Human/Mouse CD45R...View More

  • Data for Anti-Mouse CD317 (BST2, PDCA-1) Alexa Fluor® 647 (To Be Discontinued. Refer to Alternative Format: APC, cat. 17-3172).
Description

Description: The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represents a very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by antibody 120G8.

The eBio927 monoclonal antibody has also been shown to have functional activity. The epitope recognized by eBio927 is distinct from eBio129c; thus, the antibodies can be used to costain, purify and identify pDCs.

Details
Host Rat
Isotype IgG2b
Reactivity Mouse
Conjugate Alexa Fluor 647
Laser Red Laser
Emit 668 nm
Excite 633 nm
Legal Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications Flow Cytometric Analysis
Documentation

For complete product information, please download the TDS or IFU document.

TDS Link Download TDS
Additional Formats
Cat. No. Name Excite Emit Application Reg.
16-3172 Anti-Mouse CD317 (BST2, PDCA-1) Functional Grade Purified FC, FA RUO
53-3172 Anti-Mouse CD317 (BST2, PDCA-1) Alexa Fluor® 488 488 nm 519 nm FC RUO
46-3172 Anti-Mouse CD317 (BST2, PDCA-1) PerCP-eFluor® 710 488 nm 710 nm FC RUO
13-3172 Anti-Mouse CD317 (BST2, PDCA-1) Biotin FC RUO
12-3172 Anti-Mouse CD317 (BST2, PDCA-1) PE 488 - 561 nm 575 nm FC RUO
48-3172 Anti-Mouse CD317 (BST2, PDCA-1) eFluor® 450 405 nm 450 nm FC RUO
17-3172 Anti-Mouse CD317 (BST2, PDCA-1) APC 633 - 647 nm 660 nm FC RUO
11-3172 Anti-Mouse CD317 (BST2, PDCA-1) FITC 488 nm 518 nm FC RUO
14-3172 Anti-Mouse CD317 (BST2, PDCA-1) Purified FC RUO
References

References: Blasius A.L., E. Giurisat, M. Cella, R.D. Schreiber, A.S. Shaw, M. Colonna. 2006. Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in the Naïve Mouse, but a Promiscuous Cell Surface Antigen Following IFN Stimulation. J Immunol. 177:3260-3265 (927, FC, FA)

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